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GNN-014CP 



Page 1 of 2 



Customer No. 000959 

Case Docket No. GNN-014CP 



COMMISSIONER FOR PATENTS 
Box Patent Application 
Washington, D.C. 20231 



"Express Mail" Mailing Label Numbe r EL 589 752 869 US 
Date of Deposit April 12, 2001 



I liereby certify that this transmittal letter and the papers referred to as being enclosed therein are being 
deposited with the United States Postal Service "Express Mail Post Office to Addressee" service under 
37 CFR 1 . 1 0 on the date indicated ajjevy and is addressed to the^mmissioner for Patents, Box Patent 
Application, Wa^»ijig^»rpC 



Please Print Name of Person Signing 



Transmitted herewith for filing is the patent application of 

Inventor(s): Jeffrey Bluestone, Mary Collins, and Matthew Whitters 

For: SURFACE-BOUND ANTIGEN BINDING PORTIONS OF ANTIBODIES THAT BIND TO CTLA-4 AND CD28 AND 
USES THEREFOR 



□ This is a request for filing an application under 37 CFR 1 .53(b). 

1x1 77 pages of specification, ^ pages of claims, 1 pages of abstract. 

[HI 7 sheets of drawings (Figs. 1-7). 

[x1 An unexecuted Declaration, Petition and Power of Attorney. 

IHl 4 pages of Sequence Listing (numbered 1-4). 

fXl Transmittal Letter For Dislcette Containing Sequence Listing. 

[HI Dislcette Containing Sequence Listing. 



The filing fee has been calculated as shown below: 



FOR: 


NO. FILED 1 NO. EXTRA 


BASIC FEE 


iiiiii/i/iiiiiiiiiiiiiiimiiiiiii 


TOTAL CLAIMS 




22 


INDEP. CLAIMS 


4-3 


1 


\E\ MULTIPLE DEPENDENT CLAIMS PRESENTED 



* If the difference in Col. 2 is less than zero, 
enter "0" in Col. 2. 



SMALL ENTITY 



OTHER THAN 
SMALL ENTITY 



RATE 


FEE 


OR 


RATE 


FEE 


////////// 


$ 


OR 


///////// 


$ 710 


X 9= 


$ 


OR 


X 18= 


$ 396 


X 40 


$ 


OR 


X 80 


$ 80 


+135 


$ 


OR 


+270 


$ 270 


TOTAL 


0 


OR 


TOTAL 


$1456 



□ 
□ 



THE FILING FEES ARE NOT BEING PAID AT THIS TIME. 

Please charge my Deposit Account No. in the amount of $. 

A duplicate copy of this sheet is enclosed. 

A checli in the amount of $ to cover the filing fee is enclosed. 



GNN-014CP 



Page 2 of 2 



n The Commissioner is hereby authorized to charge payment of the following fees associated with this 

communication or credit any overpayment to Deposit Account No. . 

A duplicate copy of this sheet is enclosed. 

O Any additional filing fees required under 37 C.F.R. 1.16. 
Q Any patent application processing fees under 37 C.F.R. 1.17. 

n The Commissioner is hereby authorized to charge payment of the following fees during the pendency of 

this application or credit any overpayment to Deposit Account No. . 

A duplicate copy of this sheet is enclosed. 

O Any patent application processing fees under 37 C.F.R. 1.17. 

D The issue fee set in 37 C.F.R. 1.18 at or before mailing of the Notice of Allowance, 

pursuant to 37 C.F.R 1.31 1(b). 
n Any filing fees under 37 C.F.R. 1 .16 for presentation of extra claims. 

Q A check in the amount of $ to cover the recording of assignment documents 

is also enclosed. 

El 

Address all future communications (May only be completed by applicant, or attorney or agent of record) 
to Amy E. Mandragouras. Esq. at Customer Number: 000959 whose address is: 

Lahive & Cockfield, LLP 
28 State Street 
Boston, Massachusetts 02109 



Date: April 12, 2001 LAHIVE & COCKFIELD, LLP 



Megan E. Willian|is, Esq. 
Reg. No. 43,270/ 
28 State Street/ 
Boston, MA 02109 
(617) 227-7400 
Telecopier (617) 742-4214 



IN THE UNITED STATES PATENT AND TRADEMARK OFFICE 



In re the application of: Jeffrey Bluestone et al. 
Serial No.: N/A 
Filed: Herewith 

For: Surface-Bound Antigen Binding Portions of 
Antibodies That Bind to CTLA-4 and CD28 and Uses 
Therefor 

Attorney Docket No.: GNN-014CP 



Box Sequence 
Commissioner for Patents 
Washington, D.C. 20231 

TRANSMITTAL LETTER FOR DISKETTE CONTAINING SEQUENCE LISTING 

Dear Sir: 

Enclosed is a diskette which contains a computer readable form of the Sequence Listing 
for the patent application filed herewith. The Sequence Listing complies with the requirements 
of 37 C.F.R. § 1.821. The information recorded in computer readable form is identical to the 
written Sequence Listing appearing on pages 1-4 submitted herewith, as required by 37 C.F.R. § 
1 .821(f). The computer readable form of the Sequence Listing contained on the enclosed 
diskette is understood to comply with the requirements of § 1.824(d). 

Respectfully submitted, 



"Express Mail" mailing label numbe r EL 589 752 869 US 
Date of Deposi t April 12, 2001 



I hereby certify that this paper or fee is being deposited with the United States 
Postal Service "Express Mail PoshOffice to Addressee" service under 37 CFR 1.10 
on the date indicated^bove arf^^addresse^^ttJ^e Commissioner for Patents, Box 
Sequence/%stiifigt(5n, D/!/M231 




Please Print Name of Person Signing 



LAHIVE & COCKFIELD, LLP 



Megai/fi. Williams, Esq. 
Regr4^o. 43,270